Publications

Motor Function of the Two-Component EEA1-Rab5 Revealed by dcFCCS.

Methods Mol Biol, 2881 87-115 (2025)

The people behind the papers – Maarten Bebelman, Lenka Belicova and Marino Zerial.

Dev Genes Evol, 151(22) Art. No. dev204486 (2024)

Maarten P Bebelman^✳︎, Lenka Belicova^✳︎, Elzbieta Gralinska, Tobias Jumel, Aparajita Lahree, Sarah Sommer, Andrej Shevchenko, Timofei Zatsepin, Yannis Kalaidzidis, Martin Vingron, Marino Zerial

Hepatocyte differentiation requires anisotropic expansion of bile canaliculi.

Development, 151(22) Art. No. dev202777 (2024)

Nicolás Bettancourt, Cristian Pérez-Gallardo, Valeria Candia, Pamela Guevara, Yannis Kalaidzidis, Marino Zerial, Fabián Segovia-Miranda^#, Hernán Morales-Navarrete^#

Virtual tissue microstructure reconstruction across species using generative deep learning.

PLoS ONE, 19(7) Art. No. e0306073 (2024)

Dilan Martínez-Torres^✳︎, Valentina Maldonado^✳︎, Cristian Pérez-Gallardo, Rodrigo Yañez, Valeria Candia, Yannis Kalaidzidis, Marino Zerial, Hernán Morales-Navarrete^#, Fabián Segovia-Miranda^#

Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas.

Sci Rep, 14(1) Art. No. 2823 (2024)

Carlotta Mayer, Sophie Nehring, Michael Kücken, Urska Repnik, Sarah Seifert, Aleksandra Sljukic, Julien Delpierre, Hernán Morales-Navarrete, Sebastian Hinz, Mario Brosch, Brian Chung, Tom Karlsen, Meritxell Huch, Yannis Kalaidzidis, Lutz Brusch, Jochen Hampe, Clemens Schafmayer, Marino Zerial

Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease.

EMBO Rep, Art. No. doi: 10.15252/embr.202357181 (2023)

Jan Simon Schuhmacher, Susanne Tom Dieck, Savvas Christoforidis, Cedric Landerer, Jimena Davila Gallesio, Lena Hersemann, Sarah Seifert, Ramona Schäfer, Angelika Giner, Agnes Toth-Petroczy, Yannis Kalaidzidis, Katherine E Bohnsack, Markus T. Bohnsack, Erin M. Schuman, Marino Zerial

The Rab5 effector FERRY links early endosomes with mRNA localization.

Mol Cell, 83(11) 1839-1855 (2023)

Dennis Quentin^✳︎, Jan Simon Schuhmacher^✳︎, Barbara Klink, Janelle Lauer, Tanvir R. Shaikh, Pim J. Huis In ‘t Veld, Luisa M Welp, Henning Urlaub, Marino Zerial, Stefan Raunser

Structural basis of mRNA binding by the human FERRY Rab5 effector complex.

Mol Cell, 83(11) 1856-1871 (2023)

Anupam Singh, Joan Antoni Soler, Janelle Lauer, Stephan W. Grill, Marcus Jahnel, Marino Zerial, Shashi Thutupalli

Two-component molecular motor driven by a GTPase cycle.

Nat Phys, Art. No. doi: 10.1038/s41567-023-02009-3 (2023)

Maarten P. Bebelman, Matthew J. Bovyn, Carlotta M. Mayer, Julien Delpierre, Ronald Naumann, Nuno P. Martins, Alf Honigmann, Yannis Kalaidzidis, Pierre A. Haas, Marino Zerial

Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure.

Anastasia Solomatina, Alice Cezanne, Yannis Kalaidzidis, Marino Zerial, Ivo F. Sbalzarini

Design centering enables robustness screening of pattern formation models.

Bioinformatics, 38(Suppl 2) Art. No. ii134-ii140 (2022)

Aparajita Lahree, Sara de Jesus Santos Baptista, Sofia Marques, Veronika Perschin, Vanessa Zuzarte-Luís, Manisha Goel, Hadi Hasan Choudhary, Satish Mishra, Christian Stigloher, Marino Zerial, Varadharajan Sundaramurthy, Maria M Mota

Active APPL1 sequestration by Plasmodium favors liver-stage development.

Cell Rep, 39(9) Art. No. 110886 (2022)

Prasath Paramasivam, Martin Stöter, Eloina Corradi, Irene Dalla Costa, Andreas Höijer, Stefano Bartesaghi, Alan Sabirsh, Lennart Lindfors, Marianna Yanez Arteta, Peter Nordberg, Shalini Andersson, Marie-Laure Baudet, Marc Bickle, Marino Zerial

Quantitative intracellular retention of delivered RNAs through optimized cell fixation and immunostaining.

RNA, 28(3) 433-446 (2022)

Prasath Paramasivam^✳︎, Christian Franke^✳︎, Martin Stöter, Andreas Höijer, Stefano Bartesaghi, Alan Sabirsh, Lennart Lindfors, Marianna Yanez Arteta, Anders Dahlén, Annette Bak, Shalini Andersson, Yannis Kalaidzidis, Marc Bickle, Marino Zerial

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale.

J Cell Biol, 221(2) Art. No. e202110137 (2022)

German Belenguer^✳︎, Gianmarco Mastrogiovanni^✳︎, Clare Pacini^✳︎, Zoe Hall, Anna Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan E Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.

Nat Commun, 13(1) Art. No. 334 (2022)

Lenka Belicova, Urska Repnik, Julien Delpierre, Elzbieta Gralinska, Sarah Seifert, José Ignacio Valenzuela, Hernán Morales-Navarrete, Christian Franke, Helin Räägel, Evgeniya Shcherbinina, Tatiana Prikazchikova, Victor Koteliansky, Martin Vingron, Yannis Kalaidzidis, Timofei Zatsepin, Marino Zerial

Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads.

J Cell Biol, 220(10) Art. No. e202103003 (2021)

Nikoleta Kostopoulou^✳︎, Sofia Bellou^✳︎, Eleni Bagli, Maria Markou, Eleftherios Kostaras, Marko Hyvönen, Yiannis Kalaidzidis, Angelos Papadopoulos, Varvara Chalmantzi, Athena Kyrkou, Ekaterini Panopoulou, Theodore Fotsis, Carol Murphy

Embryonic stem cells are devoid of macropinocytosis, a trafficking pathway for activin A in differentiated cells.

J Cell Sci, 134(13) Art. No. jcs246892 (2021)

Anastasia Solomatina, Yannis Kalaidzidis, Alice Cezanne, Karen Soans, Caren Norden, Marino Zerial, Ivo F. Sbalzarini

Particle-based Segmentation of Extended Objects on Curved Biological Membranes.

In: ISBI 2021, IEEE International Symposium on Biomedical Imaging (ISBI) (2021), Piscataway, N.J., IEEE (2021), 1150-1154

Janelle Lauer, Marino Zerial

Profiling Structural Alterations During Rab5 Nucleotide Exchange by HDX-MS.

Methods Mol Biol, 2293 69-89 (2021)

André Scholich, Simon Syga, Hernán Morales-Navarrete, Fabián Segovia-Miranda, Hidenori Nonaka, Kirstin Meyer, Walter de Back, Lutz Brusch, Yannis Kalaidzidis, Marino Zerial, Frank Jülicher, Benjamin Friedrich

Quantification of nematic cell polarity in three-dimensional tissues.

PLoS Comput Biol, 16(12) Art. No. 1008412 (2020)

Alice Cezanne, Janelle Lauer, Anastasia Solomatina, Ivo F. Sbalzarini, Marino Zerial

A non-linear system patterns Rab5 GTPase on the membrane.

Elife, 9 Art. No. e54434 (2020)

Jens Karschau, André Scholich, Jonathan Wise, Hernán Morales-Navarrete, Yannis Kalaidzidis, Marino Zerial, Benjamin Friedrich

Resilience of three-dimensional sinusoidal networks in liver tissue.

PLoS Comput Biol, 16(6) Art. No. e1007965 (2020)

Punit Saraon, Jamie Snider, Yannis Kalaidzidis, Leanne E Wybenga-Groot, Konstantin Weiss, Ankit Rai, Nikolina Radulovich, Luka Drecun, Nika Vučković, Adriana Vučetić, Victoria Wong, Brigitte Thériault, Nhu-An Pham, Jin H Park, Alessandro Datti, Jenny Wang, Shivanthy Pathmanathan, Farzaneh Aboualizadeh, Anna Lyakisheva, Zhong Yao, Yuhui Wang, Babu Joseph, Ahmed Aman, Michael F Moran, Michael Prakesch, Gennady Poda, Richard Marcellus, David Uehling, Miroslav Samaržija, Marko Jakopović, Ming-Sound Tsao, Frances A Shepherd, Adrian Sacher, Natasha Leighl, Anna Akhmanova, Rima Al-Awar, Marino Zerial, Igor Stagljar

A drug discovery platform to identify compounds that inhibit EGFR triple mutants.

Nat Chem Biol, 16(5) 577-586 (2020)

Milena Schuhmacher, Andreas T Grasskamp, Pavel Barahtjan, Nicolai Wagner, Benoit Lombardot, Jan Simon Schuhmacher, Pia Sala, Annett Lohmann, Ian Henry, Andrej Shevchenko, Ünal Coskun, Alexander M Walter^#, André Nadler^#

Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities.

Proc Natl Acad Sci U.S.A., 117(14) 7729-7738 (2020)

Takashi Namba^#, Judit Dóczi, Anneline Pinson, Lei Xing, Nereo Kalebic, Michaela Wilsch-Bräuninger, Katherine S. Long, Samir Vaid, Janelle Lauer, Aliona Bogdanova, Barbara Borgonovo, Anna Shevchenko, Patrick Keller, David N. Drechsel, Teymuras V. Kurzchalia, Pauline Wimberger, Christos Chinopoulos, Wieland Huttner^#

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis.

Neuron, 105(5) 867-881 (2020)

Kirstin Meyer, Hernán Morales-Navarrete, Sarah Seifert, Michaela Wilsch-Braeuninger, Uta Dahmen, Elly M. Tanaka, Lutz Brusch, Yannis Kalaidzidis, Marino Zerial

Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration.

Mol Syst Biol, 16(2) Art. No. e8985 (2020)

Priyanka Sharma, Sameena Parveen, Lekha V Shah, Madhumita Mukherjee, Yannis Kalaidzidis, Anthony J Kozielski, Roberto Rosato, Jenny C Chang, Sunando Datta

SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis.

J Cell Biol, 219(1) Art. No. e201812098 (2020)

Fabián Segovia-Miranda, Hernán Morales-Navarrete, Michael Kücken, Vincent Moser, Sarah Seifert, Urska Repnik, Fabian Rost, Mario Brosch, Alexander Hendricks, Sebastian Hinz, Christoph Röcken, Dieter Lütjohann, Yannis Kalaidzidis, Clemens Schafmayer, Lutz Brusch, Jochen Hampe^#, Marino Zerial^#

Three-dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression.

Nat Med, 25(12) 1885-1893 (2019)

Janelle Lauer, Sandra Segeletz, Alice Cezanne, Giambattista Guaitoli, Francesco Raimondi, Marc Gentzel, Vikram Alva, Michael Habeck, Yannis Kalaidzidis, Marius Ueffing, Andrei N Lupas, Christian Johannes Gloeckner, Marino Zerial

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding.

Elife, 8 Art. No. e46302 (2019)

Kseniia Nikitina, Sandra Segeletz, Michael Kuhn, Yannis Kalaidzidis, Marino Zerial

Basic Phenotypes of Endocytic System Recognized by Independent Phenotypes Analysis of a High-throughput Genomic Screen.

In: Proceedings of the 2019 3rd International Conference on Computational Biology and Bioinformatics (2019), New York, ACM (2019), 69-75

Hernán Morales-Navarrete, Fabián Segovia-Miranda, Marino Zerial, Yannis Kalaidzidis

Prediction of Multiple 3D Tissue Structures Based on Single-Marker Images Using Convolutional Neural Networks.

In: 2019 IEEE International Conference on Image Processing : proceedings : September 22-25, 2019, Taipei International Convention Center (TICC), Taipei, Taiwan (2019), Piscataway, N.J., IEEE (2019), 1361-1365

Christian Franke, Urska Repnik, Sandra Segeletz, Nicolas Brouilly, Yannis Kalaidzidis, Jean-Marc Verbavatz, Marino Zerial

Correlative single-molecule localization microscopy and electron tomography reveals endosome nanoscale domains.

Traffic, 20(8) 601-617 (2019)

Hernán Morales-Navarrete^✳︎, Hidenori Nonaka^✳︎, André Scholich^✳︎, Fabián Segovia-Miranda^✳︎, Walter de Back, Kirstin Meyer, Roman L Bogorad, Victor Koteliansky, Lutz Brusch, Yannis Kalaidzidis^#, Frank Jülicher^#, Benjamin Friedrich^#, Marino Zerial^#

Liquid-crystal organization of liver tissue.

Elife, 8 Art. No. e44860 (2019)

Beatrice Senigagliesi, Carlotta Penzo, Luisa Ulloa Severino, Riccardo Maraspini, Sara Petrosino, Hernán Morales-Navarrete, Enrico Pobega, Elena Ambrosetti, Pietro Parisse, Silvia Pegoraro, Guidalberto Manfioletti, Loredana Casalis, Riccardo Sgarra

The High Mobility Group A1 (HMGA1) Chromatin Architectural Factor Modulates Nuclear Stiffness in Breast Cancer Cells.

Int J Mol Sci, 20(11) Art. No. 2733 (2019)

Livia Goto-Silva, Marisa P. McShane, Sara Salinas, Yannis Kalaidzidis, Giampietro Schiavo, Marino Zerial

Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome.

Sci Rep, 9(1) Art. No. 2433 (2019)

Egon Deyaert, Margaux Leemans, Ranjan Kumar Singh, Rodrigo Gallardo, Jan Steyaert, Arjan Kortholt, Janelle Lauer^#, Wim Versées^#

Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein.

Biochem J, 476(1) 51-66 (2019)

Martin Weigert, Uwe Schmidt, Tobias Boothe, Andreas Müller, Alexandr Dibrov, Akanksha Jain, Benjamin Wilhelm, Deborah Schmidt, Coleman Broaddus, Sian Culley, Mauricio Rocha-Martins, Fabián Segovia-Miranda, Caren Norden, Ricardo Henriques, Marino Zerial, Michele Solimena, Jochen Rink, Pavel Tomancak, Loic Royer, Florian Jug, Eugene W Myers

Content-aware image restoration: pushing the limits of fluorescence microscopy.

Nat Methods, 15(12) 1090-1097 (2018)

Hiroo Tanaka, Mitsunobu Imasato, Yuji Yamazaki, Kengo Matsumoto, Koshi Kunimoto, Julien Delpierre, Kirstin Meyer, Marino Zerial, Naho Kitamura, Mitsuhiro Watanabe, Atsushi Tamura, Sachiko Tsukita

Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice.

J Hepatol, 69(6) 1308-1316 (2018)

Oskar Knittelfelder, Sofia Traikov, Olga Vvedenskaya, Andrea Schuhmann, Sandra Segeletz, Anna Shevchenko, Andrej Shevchenko

Shotgun Lipidomics Combined with Laser Capture Microdissection: A Tool To Analyze Histological Zones in Cryosections of Tissues.

Anal Chem, 90(16) 9868-9878 (2018)

FoSheng Hsu, Stephanie Spannl, Charles Ferguson, Anthony Hyman, Robert G. Parton, Marino Zerial

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.

Elife, 7 Art. No. e32282 (2018)

Andreas Müller, Martin Neukam, Anna Ivanova, Anke Sönmez, Carla Münster, Susanne Kretschmar, Yannis Kalaidzidis, Thomas Kurth, Jean-Marc Verbavatz, Michele Solimena

A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags.

Sci Rep, 7 Art. No. 23 (2017)

Generic Properties of Stochastic Entropy Production.

Meik Dörpinghaus, Édgar Roldán, Izaak Neri, Heinrich Meyr, Frank Jülicher

An information theoretic analysis of sequential decision-making

In: 2017 IEEE International Symposium on Information Theory (ISIT) : 25-30 June 2017 (2017)(Eds.) Gerhard Kramer, Piscataway, N.J., IEEE (2017), 3050-3054

Yannis Kalaidzidis

Fluorescence Microscopy Noise Model: Estimation of Poisson Noise Parameters from Snap-Shot Image

In: Proceedings of the 2017 International Conference on Bioinformatics & Computational Biology : BIOCOMP 2017 (2017)(Eds.) Hamid R Arabnia, United States, CSREA Press (2017), 63-66

J Gray Camp^✳︎, Keisuke Sekine^✳︎, Tobias Gerber, Henry Loeffler-Wirth, Hans Binder, Malgorzata Gac, Sabina Kanton, Jorge Kageyama, Georg Damm, Daniel Seehofer, Lenka Belicova, Marc Bickle, Rico Barsacchi, Ryo Okuda, Emi Yoshizawa, Masashi Kimura, Hiroaki Ayabe, Hideki Taniguchi, Takanori Takebe^#, Barbara Treutlein^#

Multilineage communication regulates human liver bud development from pluripotency.

Nature, 546(7659) 533-538 (2017)

Christoph Metzendorf^✳︎, Anja Zeigerer^✳︎, Sarah Seifert, Richard Sparla, Bahar Najafi, François Canonne-Hergaux, Marino Zerial, Martina Muckenthaler

Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis.

Sci Rep, 7(1) Art. No. 4023 (2017)

Kirstin Meyer, Oleksandr Ostrenko, George Bourantas, Hernán Morales-Navarrete, Natalie Porat-Shliom, Fabián Segovia-Miranda, Hidenori Nonaka, Ali Ghaemi, Jean-Marc Verbavatz, Lutz Brusch, Ivo F. Sbalzarini, Yannis Kalaidzidis, Roberto Weigert, Marino Zerial

A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule.

Cell Syst, 4(3) 277-290 (2017)

Izaak Neri, Édgar Roldán, Frank Jülicher

Statistics of Infima and Stopping Times of Entropy Production and Applications to Active Molecular Processes

Physical Review X, 7(1) Art. No. 011019 (2017)

Kamil Jastrzębski, Daria Zdżalik-Bielecka, Agnieszka Mamińska, Yannis Kalaidzidis, C Hellberg, Marta Miaczynska

Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling.

J Cell Sci, 130(3) 577-589 (2017)

Anja Zeigerer, Anne Wuttke, Giovanni Marsico, Sarah Seifert, Yannis Kalaidzidis, Marino Zerial

Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance.

Exp Cell Res, 350(1) 242-252 (2017)

Izaak Neri, Fernando Lucas Metz

Eigenvalue Outliers of Non-Hermitian Random Matrices with a Local Tree Structure.

Phys Rev Lett, 117(22) Art. No. 224101 (2016)

Veronica Astro, Diletta Tonoli, Sara Chiaretti, Sabrina Badanai, Kristyna Sala, Marino Zerial, Ivan de Curtis

Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnover.

Sci Rep, 6 Art. No. 33653 (2016)

David Murray, Marcus Jahnel, Janelle Lauer, Mario Avellaneda, Nicolas Brouilly, Alice Cezanne, Hernán Morales-Navarrete, Enrico Perini, Charles Ferguson, Andrei N Lupas, Yannis Kalaidzidis, Robert G. Parton, Stephan W. Grill, Marino Zerial

An endosomal tether undergoes an entropic collapse to bring vesicles together.

Nature, 537(7618) 107-111 (2016)

Hassan Mziaut, Bernard Mulligan, Peter Hoboth, Oliver Otto, Anna Ivanova, Maik Herbig, Desiree Schumann, Tobias Hildebrandt, J Dehghany, Anke Sönmez, Carla Münster, M Meyer-Hermann, Jochen Guck, Yannis Kalaidzidis, Michele Solimena

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.

Mol Metab, 5(8) 656-668 (2016)

Hernán Morales-Navarrete, Hidenori Nonaka, Fabián Segovia-Miranda, Marino Zerial, Yannis Kalaidzidis

Automatic recognition and characterization of different non-parenchymal cells in liver tissue.

In: 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI) (2016), Piscataway, N.J., IEEE (2016), 536-540

Hao Yin, Roman L Bogorad, Carmen Barnes, Stephen Walsh, Iris Zhuang, Hidenori Nonaka, Vera M Ruda, Satya Kuchimanchi, Lubomir Nechev, Akin Akinc, Wen Xue, Marino Zerial, Robert Langer, Daniel G Anderson, Victor Koteliansky

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver.

J Hepatol, 64(4) 899-907 (2016)

Gregory A O’Sullivan, Peter Jedlicka, Hong-Xing Chen, Heba Kalbouneh, Angelo Ippolito, Thomas Deller, Ralph A Nawrotzki, Jochen Kuhse, Yannis Kalaidzidis, Joachim Kirsch, Stephan W Schwarzacher, Heinrich Betz

Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.

Mol Cell Neurosci, 72 101-113 (2016)

Kirstin Meyer

An in vivo investigation on the mechanosensory function of the mouse liver

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)

Roberto Villaseñor, Yannis Kalaidzidis, Marino Zerial

Signal processing by the endosomal system.

Curr Opin Cell Biol, 39 53-60 (2016)

Michael Kuhn, Ivica Letunic, Lars Juhl Jensen, Peer Bork

The SIDER database of drugs and side effects.

Nucleic Acids Res, 44(D1) 1075-1079 (2016)

Damian Szklarczyk, Alberto Santos, Christian von Mering, Lars Juhl Jensen, Peer Bork, Michael Kuhn

STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data.

Nucleic Acids Res, 44(D1) 380-384 (2016)

Jaime Huerta-Cepas, Damian Szklarczyk, Kristoffer Forslund, Helen Cook, Davide Heller, Mathias C Walter, Thomas Rattei, Daniel R Mende, Shinichi Sunagawa, Michael Kuhn, Lars Juhl Jensen, Christian von Mering, Peer Bork

eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.

Nucleic Acids Res, 44(D1) 286-293 (2016)

Jon M Carthy, Martin Stöter, Claudia Bellomo, Michael Vanlandewijck, Angelos Heldin, Anita Morén, Dimitris Kardassis, Timothy C Gahman, Andrew K Shiau, Marc Bickle, Marino Zerial, Carl-Henrik Heldin, Aristidis Moustakas

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.

Sci Rep, 6 Art. No. 29868 (2016)

Linda Cerofolini, Sabrina Amar, Janelle Lauer, Tommaso Martelli, Marco Fragai, Claudio Luchinat, Gregg B Fields

Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.

Sci Rep, 6 Art. No. 29511 (2016)

Édgar Roldán, Izaak Neri, Meik Dörpinghaus, Heinrich Meyr, Frank Jülicher

Decision Making in the Arrow of Time.

Phys Rev Lett, 115(25) Art. No. 250602 (2015)

Hernán Morales-Navarrete, Fabián Segovia-Miranda, Piotr Klukowski, Kirstin Meyer, Hidenori Nonaka, Giovanni Marsico, Mikhail Chernykh, Alexander Kalaidzidis, Marino Zerial^#, Yannis Kalaidzidis^#

A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture.

Elife, 4 Art. No. e11214 (2015)

Inna Kalaidzidis, Marta Miaczynska, Marta Brewińska-Olchowik, Anna Hupalowska, Charles Ferguson, Robert G. Parton, Yannis Kalaidzidis, Marino Zerial

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.

J Cell Biol, 211(1) 123-144 (2015)

Jerome Gilleron, Prasath Paramasivam, Anja Zeigerer, William Querbes, Giovanni Marsico, Cordula Andree, Sarah Seifert, Pablo Amaya, Martin Stöter, Victor Koteliansky, Herbert Waldmann, Kevin Fitzgerald, Yannis Kalaidzidis, Akin Akinc, Martin A Maier, Muthiah Manoharan, Marc Bickle, Marino Zerial

Identification of siRNA delivery enhancers by a chemical library screen.

Nucleic Acids Res, 43(16) 7984-8001 (2015)

J Dehghany, Peter Hoboth, Anna Ivanova, Hassan Mziaut, Andreas Müller, Yannis Kalaidzidis, Michele Solimena, M Meyer-Hermann

A Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells.

Traffic, 16(8) 797-813 (2015)

Jovan Tanevski, Ljupčo Todorovski, Yannis Kalaidzidis, Sašo Džeroski

Domain-specific model selection for structural identification of the Rab5-Rab7 dynamics in endocytosis.

BMC Syst Biol, 9 Art. No. 31 (2015)

Anja Zeigerer, Roman L Bogorad, Kirti Sharma, Jerome Gilleron, Sarah Seifert, Susanne Sales, Nikolaus Berndt, Sascha Bulik, Giovanni Marsico, Rochelle C J D’Souza, Naharajan Lakshmanaperumal, Kesavan Meganathan, Karthick Natarajan, Agapios Sachinidis, Andreas Dahl, Hermann-Georg Holzhütter, Andrej Shevchenko, Matthias Mann, Victor Koteliansky, Marino Zerial

Regulation of Liver Metabolism by the Endosomal GTPase Rab5.

Cell Rep, 11(6) 884-892 (2015)

Marisa P. McShane, Tim Friedrichson, Angelika Giner, Felix Meyenhofer, Rico Barsacchi, Marc Bickle, Marino Zerial

A Combination of Screening and Computational Approaches for the Identification of Novel Compounds That Decrease Mast Cell Degranulation.

J Biomol Screen, 20(6) 720-728 (2015)

Peter Hoboth, Andreas Müller, Anna Ivanova, Hassan Mziaut, J Dehghany, Anke Sönmez, Martina Lachnit, M Meyer-Hermann, Yannis Kalaidzidis, Michele Solimena

Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies.

Proc Natl Acad Sci U.S.A., 112(7) 667-676 (2015)

Roberto Villaseñor, Hidenori Nonaka, Perla Del Conte-Zerial, Yannis Kalaidzidis, Marino Zerial

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes.

Elife, 4 Art. No. e06156 (2015)

Damian Szklarczyk, Andrea Franceschini, Stefan Wyder, Kristoffer Forslund, Davide Heller, Jaime Huerta-Cepas, Milan Simonovic, Alexander Roth, Alberto Santos, Kalliopi P Tsafou, Michael Kuhn, Peer Bork, Lars Juhl Jensen, Christian von Mering

STRING v10: protein-protein interaction networks, integrated over the tree of life.

Nucleic Acids Res, 43(D1) 447-452 (2015)

Amulya Priya, Inna Kalaidzidis, Yannis Kalaidzidis, David Lambright, Sunando Datta

Molecular insights into rab7-mediated endosomal recruitment of core retromer: deciphering the role of vps26 and vps35.

Traffic, 16(1) 68-84 (2015)

Yannis Kalaidzidis, Inna Kalaidzidis, Marino Zerial

A Probabilistic Method to Quantify the Colocalization of Markers on Intracellular Vesicular Structures Visualized by Light Microscopy.

In: BAYESIAN INFERENCE AND MAXIMUM ENTROPY METHODS IN SCIENCE AND ENGINEERING (MAXENT 2014) (2015)(Eds.) A. Mohammad-Djafari, F. Barbaresco AIP Conference Proceedings ; 1641, Melville, N.Y., AIP (2015), 580-587

Dirk Drasdo, Johannes Bode, Uta Dahmen, Olaf Dirsch, Steven Dooley, Rolf Gebhardt, Ahmed Ghallab, Patricio Godoy, Dieter Häussinger, Seddik Hammad, Stefan Hoehme, Hermann-Georg Holzhütter, Ursula Klingmüller, Lars Kuepfer, Jens Timmer, Marino Zerial, Jan G Hengstler

The virtual liver: state of the art and future perspectives.

Arch Toxicol, 88(12) 2071-2075 (2014)

Mihaela Anitei, Ramu Chenna, Cornelia Czupalla, Milan Esner, Sara Christ, Steffi Lenhard, Kerstin Korn, Felix Meyenhofer, Marc Bickle, Marino Zerial, Bernard Hoflack

A high-throughput siRNA screen identifies genes that regulate mannose 6-phosphate receptor trafficking.

J Cell Sci, 127(23) 5079-5092 (2014)

Norman Gerstner

Endocytic Modulation of Developmental Signaling during Zebrafish Gastrulation

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2014)

Angela Wandinger-Ness, Marino Zerial

Rab proteins and the compartmentalization of the endosomal system.

Cold Spring Harb Perspect Biol, 6(11) Art. No. a022616 (2014)

Sandra L Schmid, Alexander Sorkin, Marino Zerial

Endocytosis: Past, Present, and Future.

Cold Spring Harb Perspect Biol, 6(12) Art. No. a022509 (2014)

Marnix Wieffer, Marisa P. McShane, Marino Zerial

Rab Proteins and the Organization of Organelle Membrane Domains.

In: Ras Superfamily Small G Proteins: Biology and Mechanisms : 2. (Eds.) Alfred Wittinghofer,Cham,Springer International Publishing (2014),17-38 Ch. 2

Angela Simeone, Giovanni Marsico, Claudio Collinet, Thierry Galvez, Yannis Kalaidzidis, Marino Zerial, Andreas Beyer

Revealing molecular mechanisms by integrating high-dimensional functional screens with protein interaction data.

PLoS Comput Biol, 10(9) Art. No. e1003801 (2014)

Enrico Perini, Ramona Schaefer, Martin Stöter, Yannis Kalaidzidis, Marino Zerial

Mammalian CORVET Is Required for Fusion and Conversion of Distinct Early Endosome Subpopulations.

Traffic, 15(12) 1366-1389 (2014)

Milan Esner, Felix Meyenhofer, Michael Kuhn, Melissa Thomas, Yannis Kalaidzidis, Marc Bickle

Development of a Kinetic Assay for Late Endosome Movement.

J Biomol Screen, 19(7) 1070-1078 (2014)

Varadharajan Sundaramurthy, Rico Barsacchi, Mikhail Chernykh, Martin Stöter, Nadine Tomschke, Marc Bickle, Yannis Kalaidzidis, Marino Zerial

Deducing the mechanism of action of compounds identified in phenotypic screens by integrating their multiparametric profiles with a reference genetic screen.

Nat Protoc, 9(2) 474-490 (2014)

Roman L Bogorad, Hao Yin, Anja Zeigerer, Hidenori Nonaka, Vera M Ruda, Marino Zerial, Daniel G Anderson^#, Victor Koteliansky^#

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice.

Nat Commun, 5 Art. No. 3869 (2014)

Anna Ivanova, Yannis Kalaidzidis, Ronald Dirkx, Mihail Sarov, Michael Gerlach, Britta Schroth-Diez, Andreas Müller, Yanmei Liu, Cordula Andree, Bernard Mulligan, Carla Münster, Thomas Kurth, Marc Bickle, Stephan Speier, Konstantinos Anastassiadis, Michele Solimena

Age-dependent labeling and imaging of insulin secretory granules.

Diabetes, 62(11) 3687-3696 (2013)

Jerome Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert, Kevin Manygoats, Sarah Seifert, Cordula Andree, Martin Stöter, Hila Epstein-Barash, Ligang Zhang, Victor Koteliansky, Kevin Fitzgerald, Eugenio Fava, Marc Bickle, Yannis Kalaidzidis, Akin Akinc, Martin A Maier, Marino Zerial

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape.

Nat Biotechnol, 31(7) 638-646 (2013)

Athena Kyrkou, M Soufi, R Bahtz, Charles Ferguson, M Bai, Robert G. Parton, Ingrid Hoffmann, Marino Zerial, Theodore Fotsis, Carol Murphy

The RhoD to centrosomal duplication.

Small GTPases, 4(2) 116-122 (2013)

A Kyrkou, M Soufi, R Bahtz, Charles Ferguson, M Bai, Robert G. Parton, I Hoffmann, Marino Zerial, Theodore Fotsis, C Murphy

RhoD participates in the regulation of cell-cycle progression and centrosome duplication.

Oncogene, 32(14) 1831-1842 (2013)

Enrico Perini

In vitro reconstitution of the molecular mechanisms of vesicle tethering and membrane fusion

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2013)

Varadharajan Sundaramurthy, Rico Barsacchi, Nikolay Samusik, Giovanni Marsico, Jerome Gilleron, Inna Kalaidzidis, Felix Meyenhofer, Marc Bickle, Yannis Kalaidzidis, Marino Zerial

Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing.

Cell Host Microbe, 13(2) 129-142 (2013)

Jerome Gilleron, Anja Zeigerer, Giovanni Marsico, Thierry Galvez, Marino Zerial

[Key role of Rab5: from endosome biogenesis to liver metabolism].

Med Sci (Paris), 28(12) 1041-1044 (2012)

Thierry Galvez, Jerome Gilleron, Marino Zerial, Gregory A O’Sullivan

SnapShot: Mammalian Rab proteins in endocytic trafficking.

Cell, 151(1) Art. No. 234-234.e2. (2012)

Lionel Foret^✳︎, Jonathan E Dawson^✳︎, Roberto Villaseñor^✳︎, Claudio Collinet, Andreas Deutsch, Lutz Brusch, Marino Zerial, Yannis Kalaidzidis, Frank Jülicher

A General Theoretical Framework to Infer Endosomal Network Dynamics from Quantitative Image Analysis.

Curr Biol, 22(15) 1381-1390 (2012)

David B Thompson, Roberto Villaseñor, Brent M Dorr, Marino Zerial, David R Liu

Cellular uptake mechanisms and endosomal trafficking of supercharged proteins.

Chem Biol, 19(7) 831-843 (2012)

Simone Fietz, Robert Lachmann, Holger Brandl, Martin Kircher, Nikolay Samusik, Roland Schröder, Naharajan Lakshmanaperumal, Ian Henry, Johannes Vogt, Axel Riehn, Wolfgang Distler, Robert Nitsch, Wolfgang Enard, Svante Pääbo, Wieland B. Huttner

Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal.

Proc Natl Acad Sci U.S.A., 109(29) 11836-11841 (2012)

C Schmees, Roberto Villaseñor, W Zheng, H Ma, Marino Zerial, Carl-Henrik Heldin, C Hellberg

Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.

Mol Biol Cell, 23(13) 2571-2582 (2012)

Julia Franziska Winter^✳︎, Sebastian Höpfner^✳︎, Kerstin Korn, Benjamin Farnung, Charles R. Bradshaw, Giovanni Marsico, Michael Volkmer, Bianca Habermann, Marino Zerial

Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity.

Nat Cell Biol, 14(7) 666-676 (2012)

Rico Barsacchi, Varadharajan Sundaramurthy, Kees Korbee, Jacques Neefjes, Tom H. M. Ottenhoff, Tiziana Scanu, Marino Zerial

Manipulating the Fight Between Human Host Cells and Intracellular Pathogens

In: Systems Microbiology: Current Topics and Applications. (Eds.) Brian D. Robertson, Brendan W. Wren,Norfolk,Caister Acad. Press (2012),77-94 Ch. 5

Anja Zeigerer, Jerome Gilleron, Roman L Bogorad, Giovanni Marsico, Hidenori Nonaka, Sarah Seifert, Hila Epstein-Barash, Satya Kuchimanchi, Chang Geng Peng, Vera M Ruda, Perla Del Conte-Zerial, Jan G Hengstler, Yannis Kalaidzidis, Victor Koteliansky, Marino Zerial

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo.

Nature, 485(7399) 465-470 (2012)

Anja Zeigerer, Jerome Gilleron, Roman L Bogorad, Giovanni Marsico, Hidenori Nonaka, Sarah Seifert, Hila Epstein-Barash, Satya Kuchimanchi, Chang Geng Peng, Vera M Ruda, Perla Del Conte-Zerial, Jan G Hengstler, Yannis Kalaidzidis, Victor Koteliansky, Marino Zerial

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo.

Nature, 485(7399) 465-470 (2012)

Matthias Stein^#, Manohar Pilli, Sabine Bernauer, Bianca Habermann, Marino Zerial, Rebecca C Wade^#

The interaction properties of the human Rab GTPase family–comparative analysis reveals determinants of molecular binding selectivity.

PLoS ONE, 7(4) Art. No. e34870 (2012)

Francisco Pan-Montojo, Mathias Schwarz, Christian Winkler, Mike Arnhold, Gregory A O’Sullivan, Arun Pal, Jonas Said, Giovanni Marsico, Jean-Marc Verbavatz, Margarita Rodrigo-Angulo, Gabriele Gille, Richard Funk, Heinz Reichmann

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice.

Sci Rep, 2 Art. No. 898 (2012)

Anton A Poznyakovskiy, Thomas Zahnert, Yannis Kalaidzidis, Nikoloz Lazurashvili, Rolf Schmidt, Hans-Jürgen Hardtke, Björn Fischer, Yury M Yarin

A segmentation method to obtain a complete geometry model of the hearing organ.

Hear Res, 282(1-2) 25-34 (2011)

Asifa Akhtar, Elaine Fuchs, Timothy J. Mitchison, Reuben J Shaw, Daniel St Johnston, Andreas Strasser, Susan Taylor, Claire E. Walczak, Marino Zerial

A decade of molecular cell biology: achievements and challenges.

Nat Rev Mol Cell Biol, 12(10) 669-674 (2011)

Anna Urbanska, Lukasz Sadowski, Yannis Kalaidzidis, Marta Miaczynska

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment

Traffic, 12(9) 1227-1241 (2011)

Iwona Pilecka, Lukasz Sadowski, Yannis Kalaidzidis, Marta Miaczynska

Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment

Exp Cell Res, 317(8) 1093-1107 (2011)

Giovanni Marsico

Analysis of the interplay between endocytosis and cell morphology through the development of computational methods

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2011)

Danming Tang, Yi Xiang, Stefano de Renzis, Jochen Rink, Gen Zheng, Marino Zerial, Yanzhuang Wang

The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle.

Nat Commun, 2 Art. No. 501 (2011)

Akhila Chandrashaker

Systems analysis of early endosome motility through identification of molecular motors

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2010)

Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K Narayanannair Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G Rajeev, William L Cantley, J Robert Dorkin, James S Butler, Liuliang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J Hope, Marino Zerial, Dinah W Y Sah, Kevin Fitzgerald, Mark A Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin de Fougerolles, Martin A Maier

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

Mol Ther, 18(7) 1357-1364 (2010)

Giovanna Mottola, Anne-Kathrin Classen, Marcos González-Gaitán, Suzanne Eaton, Marino Zerial

A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity.

Development, 137(14) 2353-2364 (2010)

Hesso Farhan, Markus W Wendeler, Sandra Mitrovic, Eugenio Fava, Yael Silberberg, Roded Sharan, Marino Zerial, Hans-Peter Hauri

MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.

J Cell Biol, 189(6) 997-1011 (2010)

Claudio Collinet, Martin Stöter, Charles R. Bradshaw, Nikolay Samusik, Jochen Rink, Denise Kenski, Bianca Habermann, Frank Buchholz, Robert Henschel, Matthias S Mueller, Wolfgang E Nagel, Eugenio Fava, Yannis Kalaidzidis, Marino Zerial

Systems survey of endocytosis by multiparametric image analysis.

Nature, 464(7286) 243-249 (2010)

Livia Goto-Silva

Characterization of APPL signalling endosomes in neurons

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2010)

Dirk Helbing, Andreas Deutsch, Stefan Diez, Karsten Peters, Yannis Kalaidzidis, Kathrin Padberg-Gehle, Stefan Lämmer, Anders Johansson, Georg Breier, Frank Schulze, Marino Zerial

Biologistics and the struggle for efficiency: concepts and perspectives

Adv complex systems, 12(6) 533-548 (2009)

Takeshi Ohya, Marta Miaczynska, Uenal Coskun, Barbara Lommer, Anja Runge, David N. Drechsel, Yannis Kalaidzidis, Marino Zerial

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.

Nature, 459(7250) 1091-1097 (2009)

Jesper B Bramsen, Maria B Laursen, Anne F Nielsen, Thomas B Hansen, Claus Bus, Niels Langkjaer, B Ravindra Babu, Torben Højland, Mikhail Abramov, Arthur Van Aerschot, Dalibor Odadzic, Romualdas Smicius, Jens Haas, Cordula Andree, Jharna Barman, Malgorzata Wenska, Puneet Srivastava, Chuanzheng Zhou, Dmytro Honcharenko, Simone Hess, Elke Müller, Georgii V Bobkov, Sergey N Mikhailov, Eugenio Fava, Thomas F Meyer, Jyoti Chattopadhyaya, Marino Zerial, Joachim W Engels, Piet Herdewijn, Jesper Wengel, Jørgen Kjems

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.

Nucleic Acids Res, 37(9) 2867-2881 (2009)

Claudio Collinet

System survey of endocytosis by functional genomics and quantitative multi-parametric image analysis

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2009)

Yonathan Lissanu Deribe, Philipp Wild, Akhila Chandrashaker, Jasna Curak, Mario Schmidt, Yannis Kalaidzidis, Natasa Milutinovic, Irina Kratchmarova, Lukas Buerkle, Michael J Fetchko, Philipp Schmidt, Saranya Kittanakom, Kevin R Brown, Igor Jurisica, Blagoy Blagoev, Marino Zerial, Igor Stagljar, Ivan Dikic

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

Sci Signal, 2(102) Art. No. ra84 (2009)

Yannis Kalaidzidis

Multiple objects tracking in fluorescence microscopy.

J Math Biol, 58(1-2) 57-80 (2009)

Charles R. Bradshaw

Improving the analysis of genome-wide screens through the detection of weakly conserved domains

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2009)

Anton A Poznyakovskiy, Thomas Zahnert, Yannis Kalaidzidis, Rolf Schmidt, Björn Fischer, Johannes Baumgart, Yury M Yarin

The creation of geometric three-dimensional models of the inner ear based on micro computer tomography data.

Hear Res, 243(1-2) 95-104 (2008)

Marisa P. McShane, Marino Zerial

Survival of the weakest: signaling aided by endosomes.

J Cell Biol, 182(5) 823-825 (2008)

Annette Schenck, Livia Goto-Silva, Claudio Collinet, Muriel Rhinn, Angelika Giner, Bianca Habermann, Michael Brand, Marino Zerial

The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.

Cell, 133(3) 486-497 (2008)

Arun Pal, Fedor F. Severin, Sebastian Höpfner, Marino Zerial

Regulation of endosome dynamics by Rab5 and Huntingtin-HAP40 effector complex in physiological versus pathological conditions

In: Small GTPases in disease. (Eds.) William E. Balch Methods in enzymology ; 438.,Amsterdam, Netherlands,Elsevier (2008),239-257 Ch. 17

Perla Del Conte-Zerial^✳︎, Lutz Brusch^✳︎, Jochen Rink, Claudio Collinet, Yannis Kalaidzidis, Marino Zerial, Andreas Deutsch

Membrane identity and GTPase cascades regulated by toggle and cut-out switches.

Mol Syst Biol, 4 206-206 (2008)

Julia Franziska Winter

Genome-wide analysis of membrane trafficking in polarised epithelial cells in the C. elegans intestine

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2008)

Yannis Kalaidzidis

Intracellular objects tracking.

Eur J Cell Biol, 86(9) 569-578 (2007)

Torben Lessmann, Michele G Leuenberger, Sascha Menninger, Meritxell Lopez-Canet, Oliver Müller, Stefan Hümmer, Jenny Bormann, Kerstin Korn, Eugenio Fava, Marino Zerial, Thomas U Mayer, Herbert Waldmann

Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase.

Chem Biol, 14(4) 443-451 (2007)

Anna Kicheva^✳︎, Periklis Pantazis^✳︎, Tobias Bollenbach^✳︎, Yannis Kalaidzidis, Thomas Bittig, Frank Jülicher^#, Marcos González-Gaitán^#

Kinetics of morphogen gradient formation.

Science, 315(5811) 521-525 (2007)

Arun Pal, Fedor F. Severin, Barbara Lommer, Anna Shevchenko, Marino Zerial

Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington’s disease.

J Cell Biol, 172(4) 605-618 (2006)

Sally Martin, Kim Driessen, Susan J. Nixon, Marino Zerial, Robert G. Parton

Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism.

J Biol Chem, 280(51) 42325-42335 (2005)

Jochen Rink, Eric Ghigo, Yannis Kalaidzidis, Marino Zerial

Rab conversion as a mechanism of progression from early to late endosomes.

Cell, 122(5) 735-749 (2005)

Gaëtane Macé, Marta Miaczynska, Marino Zerial, Angel R Nebreda

Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.

EMBO J, 24(18) 3235-3246 (2005)

Hye-Won Shin, Mitsuko Hayashi, Savvas Christoforidis, Sandra Lacas-Gervais, Sebastian Hoepfner, Markus R Wenk, Jan Modregger, Sandrine Uttenweiler-Joseph, Matthias Wilm, Arne Nystuen, Wayne N Frankel, Michele Solimena, Pietro De Camilli, Marino Zerial

An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.

J Cell Biol, 170(4) 607-618 (2005)

Lucas Pelkmans, Marino Zerial

Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae.

Nature, 436(7047) 128-133 (2005)

Sebastian Hoepfner, Fedor F. Severin, Alicia Cabezas, Bianca Habermann, Anja Runge, David J. Gillooly, Harald Stenmark, Marino Zerial

Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B.

Cell, 121(3) 437-450 (2005)

Lucas Pelkmans, Eugenio Fava, Hannes Grabner, Michael Hannus, Bianca Habermann, Eberhard Krausz, Marino Zerial

Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis.

Nature, 436(7047) 78-86 (2005)

Sebastian Höpfner

Modulation of Cargo Transport and Sorting through Endosome Motility and Positioning

Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2005)

Sebastian Hoepfner, Fedor F. Severin, Alicia Cabezas, Bianca Habermann, Anja Runge, David J. Gillooly, Harald Stenmark, Marino Zerial

Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B.

Cell, 121(3) 437-450 (2005)

Eberhard Krausz, Lucas Pelkmans, Eugenio Fava, Michael Hannus, Claudia Möbius, Kerstin Korn, Francoise Halley, Annett Lohmann, Hannes Grabner, Marino Zerial

Genomweite funktionelle Analyse des Kinoms mittels RNA-Interfernz

BIOspektrum, 11(Sonderausgabe) 518-520 (2005)

Carsten Schnatwinkel, Savvas Christoforidis, Margaret R Lindsay, Sandrine Uttenweiler-Joseph, Matthias Wilm, Robert G. Parton, Marino Zerial

The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.

PLoS Biol, 2(9) 261-261 (2004)

Lucas Pelkmans, Thomas Bürli, Marino Zerial, Ari Helenius

Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic.

Cell, 118(6) 767-780 (2004)

Marta Miaczynska, Lucas Pelkmans, Marino Zerial

Not just a sink: endosomes in control of signal transduction.

Curr Opin Cell Biol, 16(4) 400-406 (2004)

Marta Miaczynska, Savvas Christoforidis, Angelika Giner, Anna Shevchenko, Sandrine Uttenweiler-Joseph, Bianca Habermann, Matthias Wilm, Robert G. Parton, Marino Zerial

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.

Cell, 116(3) 445-456 (2004)

Stéphane Gasman, Yannis Kalaidzidis, Marino Zerial

RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.

Nat Cell Biol, 5(3) 195-204 (2003)

Rafael Mattera, Cecilia N Arighi, Robert Lodge, Marino Zerial, Juan S Bonifacino

Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.

EMBO J, 22(1) 78-88 (2003)

James T Murray, Christina Panaretou, Harald Stenmark, Marta Miaczynska, Jonathan M Backer

Role of Rab5 in the recruitment of hVps34/p150 to the early endosome.

Traffic, 3(6) 416-427 (2002)

Ekaterini Panopoulou, David J. Gillooly, Jeffrey L Wrana, Marino Zerial, Harald Stenmark, Carol Murphy, Theodore Fotsis

Early endosomal regulation of Smad-dependent signaling in endothelial cells.

J Biol Chem, 277(20) 18046-18052 (2002)

Stefano de Renzis, Birte Sönnichsen, Marino Zerial

Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.

Nat Cell Biol, 4(2) 124-133 (2002)

Marta Miaczynska, Marino Zerial

Mosaic organization of the endocytic pathway.

Exp Cell Res, 272(1) 8-14 (2002)

Roger Lippé, Marta Miaczynska, Vladimir Rybin, Anja Runge, Marino Zerial

Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex.

Mol Biol Cell, 12(7) 2219-2228 (2001)

Heike Esters, Kirill Alexandrov, Andrei Iakovenko, Tania Ivanova, Nicolas Thomä, Vladimir Rybin, Marino Zerial, Axel J. Scheidig, Roger S. Goody

Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins.

J Mol Biol, 310(1) 141-156 (2001)

Carol Murphy, Rainer Saffrich, Jean-Christophe Olivo-Marin, Angelika Giner, Wilhelm Ansorge, Theodore Fotsis, Marino Zerial

Dual function of rhoD in vesicular movement and cell motility.

Eur J Cell Biol, 80(6) 391-398 (2001)

Sandrine Uttenweiler-Joseph, Gitte Neubauer, Savvas Christoforidis, Marino Zerial, Matthias Wilm

Automated de novo sequencing of proteins using the differential scanning technique.

Proteomics, 1(5) 668-682 (2001)

Tom Van de Putte, An Zwijsen, Olivier Lonnoy, Vladimir Rybin, Miranda Cozijnsen, Annick Francis, Veerle Baekelandt, Christine A. Kozak, Marino Zerial, Danny Huylebroeck

Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development.

Mech Dev, 102(1-2) 33-44 (2001)

Marino Zerial, Heidi M. McBride

Rab proteins as membrane organizers.

Nat Rev Mol Cell Biol, 2(2) 107-117 (2001)

Savvas Christoforidis, Marino Zerial

Purification of EEA1 from bovine brain cytosol using Rab5 affinity chromatography and activity assays

In: GTPases involved in vesicular traffic. (Eds.) William E. Balch Methods in enzymology ; 329.,Amsterdam, Netherlands,Academic Press (2001),120-132 Ch. 14

Harald Stenmark, Marino Zerial

Molecular mechanisms of membrane fusion in the endocytic pathway

In: Endocytosis. (Eds.) Mark Marsh Frontiers in molecular biology ; 36.,Oxford, UK,Oxford University Press (2001),94-110 Ch. 5

Erik Nielsen, Fedor F. Severin, Anthony A. Hyman, Marino Zerial

In vitro reconstitution of endosome motility along microtubules

In: Kinesin protocols. (Eds.) Isabelle Vernos Methods in molecular biology ; 164.,Totowa, USA,Humana Press (2001),133-146 Ch. 12

Roger Lippé, Hisanori Horiuchi, Anja Runge, Marino Zerial

Expression, purification, and characterization of Rab5 effector complex, rabaptin-5/rabex-5

In: GTPases involved in vesicular traffic. (Eds.) William E. Balch Methods in enzymology ; 329.,Amsterdam, Netherlands,Elsevier (2001),132-145

Letizia Lanzetti, Vladimir Rybin, Maria Grazia Malabarba, Savvas Christoforidis, Giorgio Scita, Marino Zerial, Pier Paolo Di Fiore

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.

Nature, 408(6810) 374-377 (2000)

Erik Nielsen, Savvas Christoforidis, Sandrine Uttenweiler-Joseph, Marta Miaczynska, Frederique Dewitte, Matthias Wilm, Bernard Hoflack, Marino Zerial

Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.

J Cell Biol, 151(3) 601-612 (2000)

Sanna Lehtonen, Ari Ora, Vesa M Olkkonen, Lin Geng, Marino Zerial, Stefan Somlo, Eero Lehtonen

In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.

J Biol Chem, 275(42) 32888-32893 (2000)

Birte Sönnichsen, Stefano de Renzis, Erik Nielsen, Jens Rietdorf, Marino Zerial

Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11.

J Cell Biol, 149(4) 901-914 (2000)

Savvas Christoforidis, Marino Zerial

Purification and identification of novel Rab effectors using affinity chromatography.

Methods, 20(4) 403-410 (2000)

Mariantonietta Rubino, Marta Miaczynska, Roger Lippé, Marino Zerial

Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes.

J Biol Chem, 275(6) 3745-3748 (2000)

Savvas Christoforidis, Marta Miaczynska, Keith Ashman, Matthias Wilm, Liyun Zhao, Shu-Chin Yip, Michael D. Waterfield, Jonathan M Backer, Marino Zerial

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

Nat Cell Biol, 1(4) 249-252 (1999)

Heidi M. McBride, Vladimir Rybin, Carol Murphy, Angelika Giner, Rohan Teasdale, Marino Zerial

Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13.

Cell, 98(3) 377-386 (1999)

Jon Mulholland, James Konopka, Birgit Singer-Kruger, Marino Zerial, David Botstein

Visualization of receptor-mediated endocytosis in yeast.

Mol Biol Cell, 10(3) 799-817 (1999)

Savvas Christoforidis, Heidi M. McBride, Robert D. Burgoyne, Marino Zerial

The Rab5 effector EEA1 is a core component of endosome docking.

Nature, 397(6720) 621-625 (1999)

Sanna Lehtonen, Vesa M Olkkonen, Mark Stapleton, Marino Zerial, Eero Lehtonen

HMG-17, a chromosomal non-histone protein, shows developmental regulation during organogenesis.

Int J Dev Biol, 42(6) 775-782 (1998)

Anne Simonsen^✳︎, Roger Lippé^✳︎, Savvas Christoforidis, Jean-Michel Gaullier, Andreas Brech, Judy Callaghan, Ban-Hock Toh, Carol Murphy, Marino Zerial, Harald Stenmark

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion.

Nature, 394(6692) 494-498 (1998)

Helene Gournier, Harald Stenmark, Vladimir Rybin, Roger Lippé, Marino Zerial

Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion.

EMBO J, 17(7) 1930-1940 (1998)

Gaetano Vitale, Vladimir Rybin, Savvas Christoforidis, Per-Ove Thornqvist, Mary McCaffrey, Harald Stenmark, Marino Zerial

Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5.

EMBO J, 17(7) 1941-1951 (1998)

Harald Stenmark, Marino Zerial

Transient Expression Using the T7 RNA Polymerase Recombinant Vaccinia Virus System

In: Cell Biology: A Laboratory Handbook, 2nd Edition, Vol. 4. (Eds.) Julio E. Celis,Amsterdam, Netherlands,Academic Press (1998),201-203 Ch. 14

Paola Zacchi, Harald Stenmark, Robert G. Parton, Donata Orioli, Filip Lim, Angelika Giner, Ira Mellman, Marino Zerial, Carol Murphy

Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells.

J Cell Biol, 140(5) 1039-1053 (1998)

Harald Stenmark, Marino Zerial

Transient Expression Using the T7 RNA Polymerase Recombinant Vaccinia Virus System

In: Cell Biology: A Laboratory Handbook, 2nd Edition, Vol. 4. (Eds.) Julio E. Celis,Amsterdam, Netherlands,Academic Press (1998),201-203 Ch. 14

Harald Stenmark, Marino Zerial

Stock Preparation of Recombinant Vaccinia Virus

In: Cell Biology: A Laboratory Handbook, 2nd Edition, Vol. 1. (Eds.) Julio E. Celis,Amsterdam, Netherlands,Academic Press (1998),540-543

Marino Zerial

Membranes and sorting

Curr Opin Cell Biol, 10 475-476 (1998)

Harald Stenmark, Marino Zerial

Lipofection

In: Cell Biology: A Laboratory Handbook, 2nd Edition, Vol. 4. (Eds.) Julio E. Celis,Amsterdam, Netherlands,Academic Press (1997),141-144 Ch. 13