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We are working together

Liver Systems Medicine against Cancer

Liver Systems Medicine, or LiSyM, is a multidisciplinary research network funded by the BMBF, in which molecular and cell biologists, clinical researchers, pharmacologists, and experts in mathematical modeling examine the liver in its entirety. In LiSyM-Cancer, 42 partners at 35 academic institutions distributed over 22 locations investigate liver cancer development from pre-existing conditions such as non-alcoholic fatty liver disease (NAFLD) or cirrhosis of the liver aiming at the identification of relevant biomarkers for the early diagnosis and prevention of early liver cancer, such as Hepatocellular Carcinoma (HCC).

Our role in this research network lies in the three-dimensional visualization of healthy and pathological tissue samples with the goal of identifying a novel set of morphometric cellular tissue parameters in NAFLD indicative of disease progression.

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ENDOSCAPE is a collaborative biotechnology project funded by the EU aimed at developing a beyond state of the art clinically applicable gene delivery technology. The ENDOSCAPE technology will have a major impact on the therapeutic opportunities for current and future drugs for a broad range of diseases and large patient groups.

In this research projects we validate delivery prototypes and determine where these molecules act in the cell.

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Cluster of Excellence – Physics of Life

The Cluster of Excellence “Physics of Life” unites the University and many non-University research institutes in Dresden to elucidate the laws of physics that underlie the dynamic spatiotemporal organization of life into molecules, cells and tissues. The cluster’s focus is to bring fundamental physics to biology to understand biological questions.

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Human Frontiers Science Program Research Grant

Gaining insights into the structure and function of biological membranes is a prerequisite for understanding cell organization. Yet, we still lack an understanding of their self-organization and dynamics as well as biophysical and biomechanical properties.

In this grant entitled “Self-organization and biomechanical properties of the endosomal membrane,” we are studying biological membranes. Together with the groups of Electra Gizelli, Foundation for Research and Technology in Greece, Toshio Ando, Kanazawa University in Japan, and Andrew J. Sparkowitz at Stanford University, USA we want to understand the self-organization and mechanical properties of biological membranes using soft-matter physics, bio-sensing, microscopy, biochemistry and cell biology.